Cortical synaptic vulnerabilities revealed in an alpha-synuclein aggregation model of Parkinson's disease: Dataset for excitatory and inhibitory synaptic loci analysis
Publication Date
3-10-2025
Abstract
Tabular data for following experiments: pSyn pathology negatively impacts excitatory transmission: Electrophysiology data obtained from cortical slices. pSyn_progression__analysis_1MPI_3MPI_6MPI_SS: Microscopic data for pSyn analysis over 1month, 3 month, 6 month post-injection SEQUIN Dataset 1_3_6 MPI_Synaptic loci Frequency_Distribution_Density_SS: Excitatory and inhibitory synaptic loci quantification. syngo_annotations_NeunEnriched_DP: SynGO dataset syngo_annotations_pSynEnriched_DP: SynGO dataset Electron Microscopy analysis of Excitatory synapses pSyn pathology impact on synaptic density_pSyn and synapse loss corelation_AS: Analysis of synaptic localization of pSYN, synaptic density, and association of synaptic pSYN to pSYN positive neurites was quantified
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Zenodo
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This work is licensed under a Creative Commons Attribution 4.0 International License.
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Funder
Funder: Aligning Science Across Parkinson's
Funder DOI: 10.13039/100018231
Understanding and Manipulating Cellular and Circuit-Level Vulnerability to Neurodegeneration in Parkinson’s disease
020616
