Post-processed data for: Dopamine D1 receptor activation in the striatum is sufficient to drive reinforcement of anteceding cortical patterns
Author ORCID
Nuria Vendrell Llopis 0000-0002-8618-4247
Publication Date
10-9-2024
Abstract
This study employs two-photon calcium imaging to investigate neural activity in mice during a neuroprosthetic task. Using two-photon microscopy, we captured GCaMP8s fluorescence at a wavelength of 920nm. Mice, head-fixed on a spherical treadmill, controlled a neural cursor by modulating activity in two motor cortex neuron ensembles. The task provided auditory feedback and measured neuronal activity using dF/F ratios. Contrary to traditional neuroprosthetics, we delivered activation of dopamine receptors with photoswitches instead of water reward. We explored various experimental conditions to assess the effect of receptor activation on task performance and neuronal activity. This data set contains the post-processed data.
Keywords
FOS: Electrical engineering, electronic engineering, information engineering, FOS: Electrical engineering, electronic engineering, information engineering, dopamine receptors, d1r, brain-machine interfaces, neuroprosthetics, photo-pharmacology
Repository
Dryad
Distribution License
CC0 1.0 Universal - No copyright; this work is in the public domain
Access Instructions and Link
This data is public domain under the CC-0.0 License
Funder
Funder: National Institute on Drug Abuse
Funder ROR: https://ror.org/00fq5cm18
RF1MH123246
Funder: McKnight Brain Research Foundation
Funder ROR: https://ror.org/00vsf1v04
048240
