Document Type
Thesis
Date of Award
1981
Abstract
The purpose of this study was to differentiate patients with Alzheimer’s disease from normal aged subjects using the Luria-Nebraska Neuropsychological Test Battery (Luria-Nebraska) and the 133 Xenon inhalation method of determining regional cerebral blood flow (rCBF). In addition, correlations between rCBF detectors and Luria-Nebraska localization scales were investigated in order to ascertain possible agreement on focal areas of functional brain tissue loss. Nine subjects with Alzheimer’s disease were compared to nine normal subjects who had been matched on the basis of age, sex, race, and education. Discriminant analysis revealed 100% correct classification of all patients and normals using three of the fourteen cognitive Luria-Nebraska scales. The pattern of cognitive scale scores of the Alzheimer’s subjects was examined and compared to that seen in the normal aged subjects. Analysis of variance revealed significant differences in rCBF with Alzheimer’s subjects showing lower rCBF than normals for rCBF parameters fi (p = .003), ISI (p = .005), and wj (p = .008) but not for Phi. Concordancebetween Luria-Nebraska localization scales and rCBF detectors showed the greatest agreement between the two variables in localizing brain dysfunction throughout the posterior left cerebral hemisphere.Results were discussed and directions for further research presented.
Recommended Citation
Butler, Robert Walker, "Neuropsychological Functioning and Regional Cerebral Blood Flow: A Comparison Between Aged Normals and Alzheimer’s Type Dementia." (1981). All ETDs from UAB. 6978.
https://digitalcommons.library.uab.edu/etd-collection/6978
Comments
MA - Master of Arts; ProQuest publication number 31751898