All ETDs from UAB

Document Type

Thesis

Date of Award

1978

Abstract

Phenol. Phenol was discovered in 1834 as a byproduct of the coal gas industry and was first used to deodorize the sewers in England. Subsequently, in 1867, Joseph Lister introduced antiseptic surgery by using 5% phenol to disinfect operating room facilities and wounds (6, 25). Lister’s procedure was successful because 5% phenol causes disruption of the bacterial cell wall and precipitation of proteins. Even lower phenol concentrations can be lethal to bacteria by causing damage to the permeability barrier in the cell wall. A 1% solution has been shown to cause leakage of glutamic acid from Streptococcus faecalis. At lower concentrations (0.15%) the lethal effect is considered to be due to inactivation of essential enzyme systems (43).

Comments

MS - Master of Science/Master of Surgery; ProQuest publication number 31752077

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