Document Type
Article
Publication Title
Viruses
Abstract
Human Cytomegalovirus (HCMV) is a ubiquitous member of the Herpesviridae family, responsible for the most common congenital viral infection—congenital Cytomegalovirus (cCMV) infection. While a majority of HCMV infections in children and adults are asymptomatic, HCMV is well known to cause severe infections in the immunocompromised individual and maternal infections with variable long-term sequelae after maternal–fetal transmission with primary or nonprimary infections. HCMV seroprevalence and cCMV incidence vary by geographic area and demographic characteristics like race and socioeconomic status. While cCMV birth prevalence ranges from 0.2% to 6% in different parts of the world, it is influenced by regional HCMV seroprevalence rates. HCMV screening during pregnancy is not routinely offered due to lack of awareness, hurdles to accurate diagnosis, and lack of well-established effective treatment options during pregnancy. This review will focus on antiviral treatment options currently available for use during pregnancy and in the newborn period for the treatment of maternal and congenital HCMV infections.
DOI
https://doi.org/10.3390/v15102116
Publication Date
10-19-2023
PubMed ID
PMID: 37896892; PMCID: PMC10612073
College or School
School of Medicine
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Supplemental Associated Link
https://www.mdpi.com/1999-4915/15/10/2116
Recommended Citation
Pinninti S, Boppana S. Antiviral Treatment of Maternal and Congenital Cytomegalovirus (CMV) Infections. Viruses. 2023 Oct 19;15(10):2116. doi: 10.3390/v15102116. PMID: 37896892; PMCID: PMC10612073.
Comments
2023/2024 APC Fund Awardee:
Dr. Swetha Pinninti, Associate Professor
Heersink School of Medicine
Award Amount: $1,440.21