Advisory Committee Chair
Alecia K Gross
Advisory Committee Members
Timothy Kraft
Leo Semes
Document Type
Thesis
Date of Award
2012
Degree Name by School
Master of Science (MS) School of Optometry
Abstract
The connecting cilium serves as the major route for protein transport from the inner to outer segment of photoreceptor cells. The hypothesis that all Congenital Stationary Night Blindness (CSNB) rhodopsin mutants travel properly to the rod outer segment in Xenopus laevis will be tested by preparing transgenic X. laevis expressing a rhodopsin mutation found in human CSNB, A295V. In addition, probing for the existence of potential proteins involved in regulating rhodopsin trafficking and monitoring their localization will contribute to a better understanding of the underlying pathway of intracellular photoreceptor trafficking.
Recommended Citation
Marsh, Amie, "Localization Of Proteins Involved In Trafficking In Frog And Mouse Retina" (2012). All ETDs from UAB. 2387.
https://digitalcommons.library.uab.edu/etd-collection/2387