Advisory Committee Chair
David S Weiss
Advisory Committee Members
Mark Bevensee
Lynn Dobrunz
Kent Keyser
Kevin Kirk
Robin Lester
Document Type
Dissertation
Date of Award
2007
Degree Name by School
Doctor of Philosophy (PhD) Heersink School of Medicine
Abstract
PTX is a non-competitive antagonist of many LGICs, and its site of action is believed to be within the ion-conducting pore. This study will examine, through the use of mutagenesis, electrophysiology and homology modeling, the binding interaction between the LGIC receptors and the PTX molecule. The data provides evidence that an interaction between the PTX molecule and uncharged polar amino acids at the 6’ level of the M2 transmembrane domain are essential for PTX inhibition. While the work will focus on the γ-aminobutyric type A receptor, the pharmacological and structural relevance is attributable to the LGIC family as a whole.
Recommended Citation
Erkkila, Brian E., "Molecular Determinants Of Picrotoxin Inhibition" (2007). All ETDs from UAB. 3696.
https://digitalcommons.library.uab.edu/etd-collection/3696