Advisory Committee Chair
Alecia K Gross
Advisory Committee Members
Michael D Twa
Date of Award
Degree Name by School
Master of Science (MS) School of Optometry
Rod photoreceptors are the most prominent light sensitive cell in the retina of most mammals. The outer segments of photoreceptors contain the cellular machinery necessary for phototransduction to occur. The process of generating the phototransduction components occurs in the inner segment before being trafficked to the outer segment. These processes are highly regulated and require many different trafficking proteins and chaperones. The developmental protein nuclear distribution gene C (nudC) was found to be present in the photoreceptor, but its function is yet to be determined. Here we confirm that nudC is present in the retina and necessary in the photoreceptors. We also explore its possible functions in the post-mitotic photoreceptor cells using iCre75-nudC knockout mice.
Boehm, Skyler, "Role Of Developmental Protein, Nudc, In The Retina" (2019). All ETDs from UAB. 1193.