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Advisory Committee Chair

Alecia K Gross

Advisory Committee Members

Michael D Twa

Marina Gorbatyuk

Document Type

Thesis

Date of Award

2019

Degree Name by School

Master of Science (MS) School of Optometry

Abstract

Rod photoreceptors are the most prominent light sensitive cell in the retina of most mammals. The outer segments of photoreceptors contain the cellular machinery necessary for phototransduction to occur. The process of generating the phototransduction components occurs in the inner segment before being trafficked to the outer segment. These processes are highly regulated and require many different trafficking proteins and chaperones. The developmental protein nuclear distribution gene C (nudC) was found to be present in the photoreceptor, but its function is yet to be determined. Here we confirm that nudC is present in the retina and necessary in the photoreceptors. We also explore its possible functions in the post-mitotic photoreceptor cells using iCre75-nudC knockout mice.

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Optometry Commons

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