All ETDs from UAB

Advisory Committee Chair

Susan Miller

Advisory Committee Members

Wtimothy Garvey

Jose Fernandez

Elizabeth Kitchin

Document Type

Thesis

Date of Award

2014

Degree Name by School

Master of Science (MS) School of Health Professions

Abstract

The main purpose of this pilot study was to investigate the insulin sensitizing effect of glycine as a dietary supplement in insulin resistant (IR) normoglycemic subjects (N= 10), and to determine significant changes in insulin sensitivity and lipid profile after four weeks of glycine supplementation. Descriptive statistics were used to describe the basic characteristics of the study population. A paired t-test was used to determine differences between insulin sensitivity and lipid profile pre- and post- intervention, considering the estimation of HOMA-IR and Matsuda- index scores. Results showed that glycine supplementation might improve triglyceride (TG) levels in European Americans; and low-density lipoprotein cholesterol (LDL-c) concentrations in women after a four-week of intervention. Although, this work reports interesting results, these findings did not provide sufficient evidence to demonstrate that glycine supplementation may improve insulin sensitivity and lipid profile in insulin-resistant (IR) normoglycemic subjects. The implementation of a larger investigation with sufficient power is necessary to fully test our hypothesis and further explore these findings.

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