All ETDs from UAB

Advisory Committee Chair

Timothy Kraft

Advisory Committee Members

Clyde Guidry

Leo Semes

Document Type


Date of Award


Degree Name by School

Master of Science (MS) School of Optometry


The purpose of this project was to investigate the etiology of decreased cone-driven vision in the light damage model of retinal degenerations. Experimental albino rats underwent moderate, low-intensity light damage for 10 days. Electroretinography was utilized to assess physiologic function of the rod- and cone-driven retinal function in the experimental and control (sibling) rats. Immunohistochemical staining for cone arrestin antibody identified cone photoreceptors, allowing quantification of cone density and comparison to the decline in functional vision. In this experiment the light-damaged rats showed decreased rod- and cone-driven function with partial recovery of responses 30 days later. Outer nuclear layer thickness also decreased, as evident by optical coherence tomography and histology. LD rats showed decreased cone photoreceptor densities in the central retinal region compared to control rats. Therefore our results demonstrate that the loss of cone-driven visual function induced by light damage is at least partially due to death of cone photoreceptors.

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