All ETDs from UAB

Advisory Committee Chair

Vladimir Parpura

Advisory Committee Members

Ho-Wook Jun

Alan W Eberhardt

Document Type

Thesis

Date of Award

2012

Degree Name by School

Master of Science in Biomedical Engineering (MSBME) School of Engineering

Abstract

In this thesis, I report the use of chemically functionalized water-soluble single-walled carbon nanotubes (ws-SWCNTs) for the modulation of morpho-functional characteristics of astrocytes. When added to the culturing medium, ws-SWCNTs were able to make astrocytes larger and stellate/mature, changes associated with the increase in glial fibrillary acidic protein immunoreactivity. Thus, ws-SWCNTs could have more beneficial effects at the injury site than previously thought; by affecting astrocytes, they could provide for a more comprehensive re-establishment of the brain computational power.

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