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Advisory Committee Chair

Alecia K Gross

Advisory Committee Members

Timothy Kraft

Leo Semes

Document Type

Thesis

Date of Award

2012

Degree Name by School

Master of Science (MS) School of Optometry

Abstract

The connecting cilium serves as the major route for protein transport from the inner to outer segment of photoreceptor cells. The hypothesis that all Congenital Stationary Night Blindness (CSNB) rhodopsin mutants travel properly to the rod outer segment in Xenopus laevis will be tested by preparing transgenic X. laevis expressing a rhodopsin mutation found in human CSNB, A295V. In addition, probing for the existence of potential proteins involved in regulating rhodopsin trafficking and monitoring their localization will contribute to a better understanding of the underlying pathway of intracellular photoreceptor trafficking.

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Optometry Commons

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