Advisory Committee Chair
Nicole C Riddle
Advisory Committee Members
Stephen A Watts
Trygve Tollefsbol
Document Type
Thesis
Date of Award
2016
Degree Name by School
Master of Science (MS) College of Arts and Sciences
Abstract
Genetic regulation determines which genes are expressed, in which tissues, at which time, and to which level. This regulation is necessary for proper organismal development, and loss of gene regulation can result in phenotypic consequences. As organisms grow older, gene regulation often begins to fail, resulting in negative phenotypic outcomes associated with aging. The exact reason for this failure of gene regulation remains unknown, but current models suggest that chromatin, and its associated proteins, plays a large role. The structure of chromatin impacts gene expression, directly affecting several phenotypes including aging. In this study, we investigate HP1B, a chromatin protein, and how it affects organismal phenotypes including aging by altering chromatin structure. Our research demonstrates that deletion of HP1b alters stress resistance, changes longevity, and impacts energy metabolism.
Recommended Citation
Mills, Benjamin Mills, "A Comprehensive Investigation Of Hp1B, A Chromatin Protein, And Its Role In Aging" (2016). All ETDs from UAB. 2474.
https://digitalcommons.library.uab.edu/etd-collection/2474