All ETDs from UAB

Advisory Committee Chair

Nicole C Riddle

Advisory Committee Members

Stephen A Watts

Trygve Tollefsbol

Document Type

Thesis

Date of Award

2016

Degree Name by School

Master of Science (MS) College of Arts and Sciences

Abstract

Genetic regulation determines which genes are expressed, in which tissues, at which time, and to which level. This regulation is necessary for proper organismal development, and loss of gene regulation can result in phenotypic consequences. As organisms grow older, gene regulation often begins to fail, resulting in negative phenotypic outcomes associated with aging. The exact reason for this failure of gene regulation remains unknown, but current models suggest that chromatin, and its associated proteins, plays a large role. The structure of chromatin impacts gene expression, directly affecting several phenotypes including aging. In this study, we investigate HP1B, a chromatin protein, and how it affects organismal phenotypes including aging by altering chromatin structure. Our research demonstrates that deletion of HP1b alters stress resistance, changes longevity, and impacts energy metabolism.

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