All ETDs from UAB

Advisory Committee Chair

Linda Overstreet-Wadiche

Advisory Committee Members

Rita M Cowell

Gwendalyn D King

Lucas Pozzo-Miller

Jacques I Wadiche

Document Type

Dissertation

Date of Award

2018

Degree Name by School

Doctor of Philosophy (PhD) Heersink School of Medicine

Abstract

The dentate gyrus is a region in the adult brain where new neurons continue to be generated throughout life. While most adult-generated neurons undergo apoptosis within the first few weeks of maturation, a fraction survives and integrates into the existing circuit. It is well established that γ-aminobutyric acid (GABA) receptor-mediated mechanisms contribute to the activity-dependent regulation of adult-neurogenesis. GABAergic interneurons regulate stem cell quiescence, progenitor proliferation, and the synaptic integration of newborn neurons, however the synaptic interactions underlying integration are not fully understood. Furthermore, the impact of adult-generated neurons integrating into the existing circuit is not completely known. The collective work presented here investigates the synaptic interactions underlying the integration of adult-generated neurons in the dentate gyrus. The following experiments and results provide clarity into how GABAergic signaling, through diverse interneuron function, regulates the integration of adult-generated neurons, and further expands our understanding of how the synaptic integration of adult-generated neurons redefine the existing circuit.

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