All ETDs from UAB

Advisory Committee Chair

Maninder Kaur

Advisory Committee Members

Maria Geisinger

Nicolaas Geurs

Amjad Javed

Maninder Kaur

Document Type

Thesis

Date of Award

2019

Degree Name by School

Master of Science in Dentistry (MScD) School of Dentistry

Abstract

This study evaluated whether depression with or without the use of antidepressant was associated with changes in inflammatory markers, intraorally and systemically, GCF volume, serum biomarker levels. Cross-sectional data were collected from individuals with moderate periodontitis who were assigned to one of three groups based upon their medical history, medication usage, and answers to a validated survey instrument that assessed their level of clinical depression. Three groups of patients were compared: 1) patients with clinically diagnosed depression taking antidepressant medications [selective serotonin reuptake inhibitors (SSRIs), norepinephrine-dopamine reuptake inhibitor (NDRIs), or serotonin and norepinephrine reuptake inhibitors (SNRIs)]. 2) patients with clinically diagnosed depression not taking any antidepressant medications 3) patients not diagnosed with depression and not taking any antidepressants. In addition, gingival tissue biopsies were collected from one periodontally affected/inflamed and one healthy/non-inflamed site in the same patient and blood samples were collected on the day of tissue biopsy for gene expression and serum biomarker assay. Tissue samples were analyzed for gene expression of inflammatory biomarkers associated with periodontal disease (IL-1β, TNF-α, IFN-γ, IL-6, IL-2, IL-8, IL-10). GCF and serum samples were analyzed for proinflammatory biomarkers (IL-1β, TNF-α, IFN-γ, IL-6, IL-2, IL-8, IL-10). This study aims to evaluate whether antidepressant use improves clinical and biological markers of disease for patients with periodontitis and depression. The results show inflammatory markers being lower in Group 1 (patients taking antidepressants) compared to the patients in Group 2 (untreated clinical depression). Anti-Inflammatory marker elevation was observed on group 1 (treated clinical depression). Inflammatory biomarkers of the group 1 (using antidepressants) were lower than the ones compared to group 3 (patients with no depression diagnosed). Keywords: gingival tissue biopsies, GCF, serum samples, inflammatory biomarkers, periodontitis and depression, antidepressants.

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Dentistry Commons

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