All ETDs from UAB

Advisory Committee Chair

Trygve O Tollefbol

Advisory Committee Members

Yuanyuan Li

Bin Ren

Thane Wibbels

Nengjun Yi

Document Type


Date of Award


Degree Name by School

Doctor of Philosophy (PhD) College of Arts and Sciences


Cancer is one of the leading causes of death in the United States. Based on the American Cancer Society statistics, in 2021 1,806,590 new cancer cases and 605,520 cancer deaths are projected to occur in the United States. Amongst all, breast cancer (BC) is one of the most prevalent cancers that occurs in women. Various lifestyle factors such as alcohol intake, smoking, an unhealthy diet and physical inactivity may result in increased rates of BC risks (cancer-transition) by inducing mutations in DNA. Numerous epidemiological studies indicate that a diet rich in green tea polyphenols (GTPs), and/or cruciferous vegetables such as broccoli sprouts (BSp) consumed early in life may confer beneficial effects against the risk of developing BC. Despite recent advancements, there are many areas that remain unanswered such as how effective GTPs + BSp are when consumed early in life in preventing estrogen receptor-negative [ER(-)] BC later in life. This project explores the roles of combinatorial dietary compounds BSp and GTPs in an effort to interpret various mechanisms that are responsible for their efficacy in prevention and inhibition of BC. Our results provide preliminary evidence in understanding the impact ii of BSp + GTPs on tumor latency and progression by identifying key epigenetic alterations at the transcriptome and methylomic level in early-life as well as progeny of transgenic C3(1)/SV40 and Her2/neu mouse models.



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