All ETDs from UAB

Advisory Committee Chair

Hussein Basma

Advisory Committee Members

Amjad Javed

Nicolaas Geurs

Ramzi Abou-Arraj

Document Type

Thesis

Date of Award

2023

Abstract

Lateral ridge augmentation is a common procedure to increase the width of bone in preparation for a dental implant. A certain thickness of bone is necessary for implant health, making ridge augmentation procedures necessary for many patients. Research into the use of growth factors in ridge augmentation is ongoing, but few studies have examined the use of recombinant human platelet-derived growth factor homodimer (rhPDGF-BB) in ridge augmentation. This study examines histologic, clinical, and patient reported outcomes when horizontal ridge augmentation is completed using freeze dried bone allograft hydrated in rhPDGF-BB or saline and a resorbable crosslinked collagen membrane. Histologic results from bone cores harvested at implant placement show similar amounts of vital bone, residual graft particles, and soft tissue between treatment groups. Horizontal ridge augmentation was successful in increasing ridge width, with no statistically significant differences noted between groups. Patient reported outcomes between groups showed no statistical differences. The present study provides support for future research into the use of rhPDGF-BB in ridge augmentation.

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