Advisory Committee Chair
Palaniappan Sethu
Advisory Committee Members
Xiaoguang Liu
Gangjian Qin
Yuhua Song
Min Xie
Document Type
Dissertation
Date of Award
2022
Degree Name by School
Doctor of Philosophy (PhD) School of Engineering
Abstract
The primary goal of this study is to evaluate the effect of diminished pulsatility associat-ed with Continuous Flow Ventricular Assist Devices (CF-VADs) on endothelial respons-es of pro-angiogenic/proinflammatory soluble factors and von Willebrand Factor (vWF). Non-surgical bleeding is one of the most common adverse events after CF-VAD implan-tation and is a major cause of morbidity in patients supported by CF-VAD therapy. Alt-hough the exact mechanisms remain unclear, development of arteriovenous malfor-mations (AVMs) and acquired von Willebrand factor syndrome (AVWS) are widely be-lieved to be major risk factors. Another challenge with the study of pulsatility is that pre-clinical studies to understand how loss of pulsatility contributes to non-surgical bleeding in CF-VAD recipients are very limited because of the lack of relevance and insufficient translation of results from available animal models. Therefore, in this project, we propose a comprehensive approach using an in-vitro Vessel-on-a-chip model – our Vascular Pulse Perfusion Model (VPPM), coupled with evaluation of blood samples from CF-VAD pa-tients, to study the effect of diminished pulsatility associated with CF-VAD on endotheli-al responses via pro-inflammatory/pro-angiogenic soluble factors and endothelial vWF.
Recommended Citation
Nguyen, Khahn Tu, "How Does Loss of Pulsatility Lead to Non-Surgical Bleeding in Continuous Flow Ventricular Assist Device Patterns" (2022). All ETDs from UAB. 355.
https://digitalcommons.library.uab.edu/etd-collection/355