All ETDs from UAB

Advisory Committee Chair

Donald B Twieg

Advisory Committee Members

Edward G Walsh

Paul D Gamlin

Document Type


Date of Award


Degree Name by School

Master of Science in Biomedical Engineering (MSBME) School of Engineering


MRI can be employed to measure blood flow changes, which is an important in-dex of tissue health and function. One of the methods used to quantify perfusion is Ar-terial Spin Labeling (ASL) - a non-invasive method that uses arterial blood water as an endogenous contrast agent. The aim of this study was to quantify cerebral blood perfusion in awake, behaving non-human primates by using a class of techniques called Continuous Arterial Spin Labe-ling (CASL). This study involved the experimental design, setup and post-processing for the measurement of perfusion to facilitate validation studies in animals and compare them with existing perfusion estimates in humans. The CASL sequence was implemented and perfusion was quantified in awake, behaving non-human primates. Optimal parameters determined for perfusion quantifica-tion included a labeling power = 2W and post labeling delay=0.5s. A labeling efficiency of 88% and a labeling time of 2s were used. The fractional signal difference in gray mat-ter (GM) was 2.52% and in white matter (WM) was 1.11%. The average quantified GM CBF was 60.29 ± 5.42 ml/100g/min and WM CBF was 26.33 ± 4.62 ml/100g/min. GM/WM ratio was 2.35 ± 0.52. An analysis of the data suggests that functional studies in non human primates using CASL may be feasible. The results of this study will help in better understanding iii quantitative perfusion estimates in awake, behaving non-human primates and how they compare with corresponding cerebral blood flow (CBF) values in humans.

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