All ETDs from UAB

Advisory Committee Chair

Gordon Fisher

Advisory Committee Members

Gary Hunter

Douglas Moellering

Document Type


Date of Award


Degree Name by School

Master of Science (MS) School of Education


Background: Oxidative stress induced by “free radicals” plays role in vascular dysfunction and cardiovascular health. Studies exploring beneficial effects of chronic aerobic training by enhancing antioxidant mechanisms in the body and thus, hemodynamic outcome measures are limited. Purpose: To assess effects of chronic aerobic exercise training on association between change (Δ) in antioxidant capacity, measured in terms of ferric reducing ability of plasma (ΔFRAP), and change in vascular hemodynamic (outcome) measures: systolic blood pressure (ΔSBP), diastolic blood pressure (ΔDBP), large arterial elasticity index (ΔLAEI) and small arterial elasticity index (ΔSAEI), in a cohort of healthy women. Methods: This was a secondary data analysis of a study designed to evaluate cardiometabolic outcomes. Participants performed 12-weeks of supervised aerobic exercise 3 times/week on stationary cycle ergometer. Change in FRAP and hemodynamic measures was calculated using baseline and post-training (wk 12) values. Results: Analysis included 29 healthy females (African-Americans=15, Caucasians=14) with mean age of 32 years. Significant negative correlation between ΔFRAP and ΔDBP (r=-0.48, p=0.01) and positive correlation between ΔFRAP and ΔSAEI (r=0.38, p=0.04) iii were observed. In multiple regression analyses, a model with ΔFRAP and ΔSAEI significantly predicted ΔDBP (p=0.02) with ΔFRAP (p=0.04) having an independent significant effect. In a model of ΔSBP although overall effect of ΔFRAP and ΔSAEI was significant (p=0.04), ΔFRAP (p=0.25) did not have significant independent effect. Conclusion: When antioxidant capacity of plasma changes after exercise training, this may be related to the changes in diastolic blood pressure and small arterial elasticity.

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