Advisory Committee Chair
Advisory Committee Members
Maria L Geisinger
Date of Award
Degree Name by School
Master of Science (MS) School of Dentistry
Objective: The present randomized controlled clinical trial aims to evaluate clinically, radiographic, and histologically the efficacy of L-PRF in combination with FDBA either in a homogeneous mixture or using a layered technique in improving quantity and quality of new vital bone formation and alveolar ridge dimensional stability in comparison to LPRF alone for ridge preservation after tooth extraction. Materials and Methods: Twentythree patients successfully completed the study. They were randomized to receive either L-PRF/FDBA layered technique (LAY), L-PRF/FDBA homogeneous mixture (MIX), or L-PRF alone. After minimally traumatic tooth extraction, direct clinical assessment and a Cone-Beam Computed Tomography (CBCT) scan were taken. The socket was grafted following the corresponding group technique. After an average of 16 + 4 weeks of healing, clinical measurements, a second CBCT scan, and bone core biopsy and dental implant placement were performed. Vertical and horizontal dimensional changes were assessed clinically by direct measurement, and radiographically by CBCT superimposition technique using coDiagnosticXTM software. Bone cores were analyzed by histomorphometric analysis. ANOVA F test, Fisher’s test and Tukey’s HSD test were conducted to compare the outcomes between the three groups. Results: The mean loss clinically of ridge in width was 0.83 + 2.7 mm and the mean loss clinically in ridge iv height was 0.55 + 1.91 mm. L-PRF/FDBA MIX group demonstrated the least dimensional changes in ridge width (0.78 + 3.8 mm, 0.48 + 1.93 mm) and ridge height (0.07 + 3.19 mm, 0.91 + 1.18 mm) clinical and radiographically respectively, with no statistically significant differences between groups. Histomorphometrically, LPRF/FDBA MIX group demonstrated the highest percentage of new vital bone (58.26% + 2.84%) and was statistically significantly greater than the L-PRF group (38.59% + 10.12%). LPRF/ FDBA LAY group demonstrated less percentage of residual graft particles (12.23% + 6.57%) than the L-PRF/FDBA MIX group (14.18% + 4.69). L-PRF group demonstrated significant greater percentage of soft tissue (49.68% + 16.21%) than LPRF/ FDBA MIX group. Conclusion: These findings have demonstrated L-PRF is a suitable biomaterial for ridge preservation used alone or in combination with allograft. All techniques assessed provided acceptable dimensional ridge changes and adequate new bone formation for implant therapy.
Galvis, Geisy, "Clinical, Radiographic, and Histomorphometric Outcomes Following Ridge Preservation Using Leukocyte- and Platelet-Rich Fibrin (L-PRF) and Freeze-Dried Bone Allograft (FDBA) Layered Technique: A Prospective, Randomized Clinical Trial" (2021). All ETDs from UAB. 614.