Document Type
Thesis
Date of Award
1980
Abstract
Following the suggestion by Smythies that the major hallucinogens, mescaline, N,N-dimethyltryptamine (DMT) and d-lysergic acid diethylamide (d-LSD) all act at the same site, namely, the serotonin (5-hydroxytryptamine) receptor in the brain, it was found that 1-methyl-1,2,5, 6-tetrahydropyridine-3-(N,N-diethylcarboxamide) (THPC), a compound similar in structure to the D-ring of LSD (Figure 1), blocked the behavioral disruption in rats induced by LSD as measured by Bovet-Gatti profiles on a Sidman avoidance schedule. Further studies by Christian et al. firmly established that THPC acts as a LSD antagonist since binding of LSD to a high affinity site on thesynaptosomal membrane is completely blocked by THPC. Dyer et al. showed that contractions of sheep umbilical vasculature induced by 5-hydroxytryptamine, mescaline and LSD are blocked by THPC acting as a serotonin receptor antagonist. This study also demonstrated that although THPC acts as a hallucinogen antagonist, it is not as potent as other known antagonists such as 2-bromolysergic acid die-thylamide or cinanserin (N-[2-(3-N,N-dimethylaminopropylthio)-phenyl) cinnamide).
Recommended Citation
Panu, Al Mukendi, "Synthesis and Characterization of 1-Methyl-4-Substituted-3-Piperidine-Carboxylic Acid N, N-Diethyamide." (1980). All ETDs from UAB. 7102.
https://digitalcommons.library.uab.edu/etd-collection/7102
Comments
MS - Master of Science/Master of Surgery; ProQuest publication number 31752022