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Advisory Committee Chair

David E Vance

Advisory Committee Members

Michael Crowe

Pariya L Fazeli

Document Type

Thesis

Date of Award

2021

Degree Name by School

Master of Arts (MA) College of Arts and Sciences

Abstract

People with HIV (PWH) are at an increased risk for everyday functionalimpairment, especially as they age. The purpose of this study was: (1) to identify factors associated with subjective and objective instrumental activities of daily living (IADL) difficulty in PWH and (2) to identify factors associated with awareness of functional capacity. This cross-sectional study included 261 PWH. Participants completed a comprehensive neurobehavioral assessment, including self-report and performance-based measures of everyday functioning. Hierarchical multiple regressions were performed to identify health, psychological, and cognitive factors that contribute to subjective and objective evaluation of everyday functioning. We also examined factors that predicted a discrepancy between self-report and performance-based measure of IADLs. Greater depression was a consistent predictor of worse self-reported everyday functioning while cognitive domains were better predictors of worse performance on an objective task of everyday functioning. Processing speed predicted discrepancy between subjective and objective performance of IADLs. Inaccurate self-reporters had worse cognitive functioning, as well as lower openness, conscientiousness, and agreeableness. Better characterization of factors associated with IADL difficulties may elucidate targets for interventions designed to optimize aging in PWH.

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