All ETDs from UAB

Advisory Committee Chair

Gordon Fisher

Advisory Committee Members

Fernando Ovalle

Rakesh Patel

Eric Plaisance

Document Type

Thesis

Date of Award

2020

Degree Name by School

Master of Science (MS) School of Education

Abstract

Cardiometabolic diseases are becoming increasingly prevalent in modern society due to low activity lifestyles and poor nutrition. Inorganic dietary nitrate (diNO3) has shown to potentially improve cardiometabolic health in a number of different populations but remains to be corroborated in humans with type 2 diabetes (T2D). This preliminary analysis aimed to determine the effects of consuming an acute, concentrated dose of diNO3 containing beetroot juice (BRJ) on hemodynamic and glycemic responses in humans with T2D while controlling for pharmacological influences. Three participants with a clinical diagnosis of T2D were recruited into this study. Pulsewave Velocity (PWV) was used to assess hemodynamic responses and an Oral Glucose Tolerance Test (OGTT) was used to measure glycemic responses following the consumption of BRJ or a denitrolized BRJ placebo. Hemodynamic (systolic blood pressure, diastolic blood pressure, and systemic vascular resistance) and OGTT outcomes (Matsuda, HOMA, and QUICKI) were assessed between conditions. Blood plasma and saliva were collected at baseline, two hours post BRJ consumption, and immediately following the OGTT test to assess changes in nitrate and nitrite concentrations. The results from this preliminary study showed that acute ingestion of BRJ led to a decrease in systemic vascular resistance (SVR). Calculated SVR change scores showed dramatic decreases in response to the consumed nitrate (p = 0.036). Using Pearson’s R, SVR was shown to have a very strong correlation to plasma nitrate (R = -0.986) yet was not detected to be significant (p = 0.107). While all NOx responses were observed to peak at expected rates, the only variable in which we were able to detect a significant difference from baseline to the two-hour timepoint was plasma nitrate concentrations. No other hemodynamic or glycemic responses were observed following acute BRJ supplementation.

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