All ETDs from UAB

Advisory Committee Chair

Candace L Floyd

Advisory Committee Members

Stephen A Watts

Jerzy P Szaflarski

Document Type

Thesis

Date of Award

2017

Degree Name by School

Master of Science (MS) College of Arts and Sciences

Abstract

In the United States, 2.5 million people experience a traumatic brain injury (TBI) every year and an estimated 5.3 million are living with a TBI-related disability. A TBI alters the function of the brain and the brain pathology often resulting in long-lasting cognitive impairment, motor function impairments, and emotional changes. In conjunction with the physical changes a victim of TBI experiences, the injury can take a financial toll. It is estimated that 76.3 billion dollars is attributed to the direct and indirect costs of sustaining a TBI every year in the United States. Despite improvements in managing TBI, there are currently no neuroprotective drugs available. This thesis is composed of a study to evaluate Perampanel (PRM), also known as Fycompa ®, and its potential as a neuroprotective agent in TBI. PRM is a selective noncompetitive AMPA receptor antagonist and is approved as an antiepileptic in the United States and Europe. This thesis investigates the effects of Perampanel on subacute biomarkers of neuroprotection in relation to cognitive deficits. Such parameters include learning and memory, anxiety, and reward-seeking/motivation implications. Keywords: traumatic brain injury-Perampanel-Fycompa-neuroprotection-AMPA receptor-AMPA receptor antagonist

Share

COinS