Document Type
Article
Publication Title
American Journal of Tropical Medicine and Hygeine
Abstract
The seroprevalence and incidence of Helicobacter pylori infection were determined among 312 North American missionaries who were serving in developing countries between 1967 and 1984. The majority (81%) resided in sub-Saharan Africa. When initially evaluated, the missionaries had a mean age of 40 years, 65% were female, and all were of white race/ethnicity. An ELISA showed that the initial prevalence of IgG antibody to H. pylori was 17%. After a mean of 7.4 years of service (1917 person-years of exposure), 37 (14%) of 259 initially seronegative subjects seroconverted to anti-H. pylori, giving an annual incidence of 1.9%. These data indicate a relatively higher risk of H. pylori infection among missionaries compared with an annual incidence of seroconversion of 0.3–1.0% in industrialized nations. Long-term residents in developing countries should be evaluated for H. pylori infection when gastrointestinal symptoms develop.
Publication Date
1999
Supplemental Associated Link
https://www.ajtmh.org/view/journals/tpmd/60/2/article-p267.xml
Recommended Citation
Becker, Sylvia I.; Smalligan, Roger D.; Frame, John D.; Kleanthous, Harry; Tibbitts, Timothy J.; Monath, Thomas P.; and Hyams, Kenneth C., "Risk of Helicobacter Pylori Infection Among Long-Term Residents in Developing Countries" (1999). UABH Articles. 4.
https://digitalcommons.library.uab.edu/uabh-articles/4
