Advisor(s)

Jillian Ziemanski

Committee Member(s)

Amber Gaume
Edmund Arthur

Document Type

Thesis

Date of Award

1-27-2026

Degree Name

Master of Science (MS)

School

School of Optometry

Department

Vision Science

Abstract

Both Sjögren’s disease and glaucoma are known to have abnormal corneal biomechanics that impact their disease progression. The pathophysiology of Sjögren’s disease may also increase the likelihood of developing glaucoma. However, we do not yet know whether the prevalence of risk factors associated with glaucoma in Sjögren’s patients is due to underlying weakened corneal biomechanics. Oculus Corvis ST will be used to evaluate the corneal biomechanics in Sjögren’s patients in relation to the inflammatory mediators in the tear film. These properties will then be correlated with retinal nerve fiber layer and ganglion cell layer thickness. Evaluating these findings will provide more information on whether there is a correlation between risk factors of glaucoma, represented by retinal nerve fiber layer thickness, and weakened corneal biomechanics in Sjögren’s patients. This knowledge will impact the screening of Sjögren’s patients for glaucoma and the subsequent management of those patients.

Keywords

complement;corneal biomechanics;dry eye;glaucoma;Sjögren’s disease;Sjögren’s syndrome

ProQuest Publication Number

32284749

ISBN

9798273381124

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