All ETDs from UAB

Authors

Advisor(s)

Kristen L Triebel

Committee Member(s)

Thomas Novack

Michael Crowe

Richard Kennedy

Document Type

Thesis

Date of Award

2017

Abstract

Objective: To examine whether cognitive reserve (CR) attenuates the initial impact of TBI on cognitive performance (passive model) and results in faster cognitive recovery rates in the first year post-injury (active model), and whether the advantage of CR differs based on the severity of TBI. Setting: Inpatient/outpatient clinics at academic medical center. Participants: Adults with mild TBI (mTBI; n=28), complicated mild TBI (cmTBI; n=24), and moderate-to-severe TBI (msevTBI; n=57), and demographically-matched controls (n=66). Design: Retrospective; longitudinal cohort assessed at 1-, 6-, and 12-months post-injury. Main Measures: Outcomes were 3 cognitive domains: processing speed/executive function, verbal fluency, and memory. Premorbid IQ, estimated with the Wechsler Test of Adult Reading, served as CR proxy. Results: Higher premorbid IQ was associated with better performance on cognitive domains at one-month post-injury, and the effect of IQ was similarly beneficial for all groups. Cognitive recovery rate was moderated only by TBI severity; those with more severe TBI had faster recovery in the first year. Conclusion: Results provide evidence for the passive, but not active, model of CR during TBI recovery. Specifically, the mechanism for the passive model is preservation of the pre-injury relationship between CR and cognition. CR does not moderate the rate of recovery.

ProQuest Publication Number

Document on ProQuest

ISBN

978-1-369-82607-4

Comments

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