Advisory Committee Chair
Stephen Mitchell
Advisory Committee Members
Jane Sande
Noel K Childers
Gretchen Cloud
Firoz Rahemtulla
Document Type
Thesis
Date of Award
2008
Degree Name by School
Master of Science (MS) School of Dentistry
Abstract
Purpose: The purpose of this retrospective study was to identify the factors that influence the incidence, severity, onset, and resolution of oral mucositis in children undergoing bone marrow transplantation (BMT). Methods: One hundred and fifty medical records were reviewed of patients that received BMT. Daily values of white blood cell (WBC) counts were obtained to associate it’s correlation with the incidence, severity, onset, and resolution of oral mucositis. Age group and gender of the patients, type of bone marrow transplant, the use of methotrexate, the use of total body irradiation, and the previous treatment with chemotherapy were obtained to analyze the incidence, severity, onset, and resolution of oral mucositis for each of the variables. Results: Seventy six medical records met the inclusive criteria. The incidence of mucositis was 88%. Of the patients that developed mucositis, 74% experienced the non-severe type and 26% developed severe mucositis. The onset of mucositis was hospital ii day 9. By hospital day 21, patients had recovered from mucositis. A negative correlation (r= -0.46096) was found between the overall entries of WBC and the oral scores. For the patients that developed mucositis, the WBC counts were lower when compared to the patients that did not develop mucositis (p< 0.0001). Patients with severe mucositis patients had considerable lower WBC counts (p< 0.0001). The previous history of chemotherapy showed statistical difference at the incidence of mucositis (p= 0.06). Patients with autologous, cord blood, and haploidentical type of transplants developed oral mucositis ealier when compared to the matched related and matched unrelated types (p= 0.005). The use of methotrexate showed statistical difference at the onset of mucositis (p< 0.0001). For the resolution of mucositis, none of the variables showed statistical difference. Conclusions: A negative correlation was found between the WBC counts and the oral score. The incidence of mucositis was influenced by periods of leukopenia and the use of methotrexate. WBC counts were significant lower in patients with the severe type of oral mucositis. The onset of mucositis was influenced by the type of BMT and the use of methotrexate.
Recommended Citation
Rodriguez, Francisco Jose, "Oral Mucositis In Children Receiving Bone Marrow Transplantation" (2008). All ETDs from UAB. 3627.
https://digitalcommons.library.uab.edu/etd-collection/3627
