School
School of Public Health
Document Type
Dissertation
Department (new version)
Public Health
Date of Award
1990
Degree Name by School
Doctor of Public Health (DrPH) School of Public Health
Abstract
In order to identify maternal risk factors for intrauterine transmission of cytomegalovirus (CMV), a case-control study of 175 mothers of children with congenital CMV infection was undertaken. Cases and 358 randomly selected controls delivered newborns in University Hospital between 1980 and 1988. During this interval, all newborns were tested for viruria. Maternal demographic features, pregnancy complications, and sexually transmitted infections were identified by medical records review. Eighty-four percent of the study population was black and over 95% received prenatal care; there was no difference between cases and controls in these two variables. Multiple logistic regression analyses were performed and after adjustment for other risk factors, there was an increased risk among women who were younger (odds ratio = 2.2, 95% confidence interval 1.4-3.4), unmarried (OR = 1.6, 0.9-2.7), and primiparous (OR = 1.8, 1.2-2.8). Women with gonorrhea (OR = 2.0, 1.1-3.9), trichomoniasis (OR = 2.5, 1.4-4.3), or bacterial vaginosis (OR = 2.1, 1.0-4.6) had an increased risk of delivery of a CMV-infected newborn. Women with primary CMV infections during pregnancy which resulted in congenital infections had increases in sexually transmitted infections during pregnancy (OR = 1.8, 0.7-4.7), with trichomoniasis (OR = 5.0, 1.2-30.2) most strongly associated with in utero transmission of CMV. These results in a predominantly black, low-income population indicate a greater risk for congenital CMV infection in offspring of young, single, primiparous mothers. The association with gonorrhea and other sexually transmitted infections suggest that in this population maternal CMV infection may be related to sexual activity. However, it is also possible that other sexually transmitted infections are not only indicators of sexual activity, but are promoters of CMV infection.
ProQuest Publication Number
ProQuest ID
9101308
ISBN
979-8-207-42329-6
Recommended Citation
Fowler, Karen Breazeale, "A case-control study of sexually transmitted infections in mothers of newborns with congenital cytomegalovirus infections" (1990). All ETDs from UAB. 7169.
https://digitalcommons.library.uab.edu/etd-collection/7169
Comments
DrPH