Advisor(s)
Chin-Chuan Fu
Committee Member(s)
Amjad Javed
Nathaniel C Lawson
Ping Zhang
Wenchou Wu
School
School of Dentistry
Document Type
Thesis
Department (new version)
Dentistry
Date of Award
6-4-2025
Abstract
Background: PMMA denture base resins have high propensity for C. albicans growth. Previous studies have found that silver nanoparticle (SNP) addition into conventional PMMA resin improves fungal resistance without interfering with its flexural strength. Recently, CAD/CAM dentures have become highly popular, but they are also prone to fungal in-growth. However, little is known about the effect of addition of silver nanoparticles in CAD/CAM printed PMMA resin material. Objective: To compare the effect of the addition of cytocompatible concentration (1 µm/ml) of SNP on the antifungal efficacy and flexural strength of CAD/CAM printed and heat-cured PMMA polymers. Materials and methods: A total of 110 samples (66 unmodified and 44 modified with SNP) of three different denture materials, heat-cured PMMA (Lucitone 199, Dentsply International Inc., York, PA, USA), CAD/CAD milled (Ivotion base, Ivoclar, USA), and CAD/CAD printed denture material (Dentca Denture base II, Dentca Inc, CA, USA) were tested. Optical density at 600nm (OD600) was used to measure C. albicans adherence and a three-point bending test was performed to analyze the flexural strength. Data analysis was conducted with SPSS version 29, using Kruskal-Wallis test with Bonferroni correction for C. albicans adherence and ANOVA for flexural strength. Results: A statistically significant difference was observed for C. albicans adherence between different groups (p=.001). SNP incorporation reduced C. albicans adherence to Lucitone 199 heat cured PMMA and Dentca II printed denture base resin. Lucitone heat cured and lucitone heat cured with SNP were significantly different than Ivotion milled base, that showed highest C. albicans adherence. However, no statistically significant difference was observed between different groups (p>0.05) for flexural strength. The mean flexural strength of Dentca printed material modified with SNP was highest and unmodified Dentca printed material was the lowest. The Lucitone 199 unmodified heat cured material had higher flexural strength than Ivotion base milled material. Conclusions: Different denture base resin materials have different flexural strength and candida albicans adherence. Addition of SNP to Dentca denture base II printed resin improves both its flexural strength and fungal resistance, making its characteristics close to Lucitone 199 heat cured PMMA resin. Further research is needed to develop standardized protocols for modifying denture base materials with silver nanoparticles before these materials can be recommended for clinical use.
ProQuest ID
Recommended Citation
Aggarwal, Himanshi, "Antifungal Efficacy And Flexural Strength Of Silver Nanoparticles Reinforced Cad/Cam And Heat-Cured Pmma Polymers: An In-Vitro Study" (2025). All ETDs from UAB. 7278.
https://digitalcommons.library.uab.edu/etd-collection/7278
