Advisor(s)
Gordon Fisher
Committee Member(s)
Fernando Ovalle
Rakesh Patel
School
School of Education
Document Type
Thesis
Department (new version)
Education
Date of Award
9-9-2024
Abstract
The prevalence of cardiometabolic diseases has continued to rise within the United. Physical activity and poor dietary choices are two factors that are known to contribute to the rise in cardiometabolic diseases. Thus, it is critical to identify strategies that may mitigate the negative impact from these behaviors. Several recent studies have shown that consumption of dietary inorganic nitrate (diNO3) may improve vascular health and glucose regulation in animal models and some human studies. However, the improvements in glucose regulation have yet to be corroborated in humans with type 2 diabetes (T2D). Thus, the purpose of this study was to assess the acute effects of diNO3 containing beetroot juice (BRJ) on glycemic and hemodynamic responses in individuals with T2D while controlling for medication. Seven participants with a clinical diagnosis of T2D were recruited into this study. Pulsewave analysis was used to assess hemodynamic measurements and an oral glucose tolerance test (OGTT) to measure glycemic responses following consumption of either BRJ or a denitrolized placebo condition. Hemodynamic responses and glycemic responses were compared between the two conditions. Saliva and blood samples were collected at baseline, two hours post supplementation and following the OGTT to measure any changes in nitrate and nitrite concentrations. Data from our assessment showed ingestion of diNO3 significantly improved plasma glucose response at 60, 90 and 120 minutes during the 2 hour OGTT (p < .05). Results also showed an increase in salivary and plasma nitrate concentrations 2 and 4 hours after BRJ ingestion (p < .05). No other glycemic or hemodynamic variables showed any significant change. This study demonstrated that BRJ consumption can improve oral glucose tolerance in individuals with T2D while controlling for medication, however future larger-cohort randomized controlled trials are needed to confirm if BRJ is a viable treatment glucose control in individuals with T2D.
ProQuest ID
Recommended Citation
Tyler, Andrew, "The Effects Of Acute Beetroot Juice Intake On Glycemic And Blood Pressure Responses When Controlling For Medication In Individuals With Type 2 Diabetes" (2024). All ETDs from UAB. 7595.
https://digitalcommons.library.uab.edu/etd-collection/7595
