Data sets v.1.1 for Perspective: SARS-CoV-2 may regulate cellular responses through depletion of specific host miRNAs
Author ORCID
Rafal Bartoszewski 0000-0002-2864-6757
Publication Date
7-29-2020
Abstract
The list of potential (bioinformatic predictions) interactions of human miRNA with 7 coronavirus genomes that include 3 pathogenic and 4 non-pathogenic coronaviruses. (Data Set 1). The HCoVs' RNA genomes of pathogenic strains were SARS-CoV-2 (NC_045512.2), SARS-CoV (NC_004718.3), MERS-CoV (NC_019843.3). The non-pathogenic strains were HCoV-OC43 (KU131570.1), HCoV-229E (NC_002645.1), HCoV-HKU1 (KF686346.1), and HCoV-NL63 (NC_005831.2). These coronaviruses were tested against the set of 896 confident mature human miRNA sequences that were obtained from the miRBbase v2.21 using the RNA22 v2 microRNA target discovery tool web-server. In order to reduce the false discovery rate of the MTS predictions, the most strict parameters were applied to the default computation workflow using a specificity of 92% versus a sensitivity of 22%.
Data set 2. The potential targets of miRNA that could be bound to either the pathogenic, the non-pathogenic or both groups of HCoVs. Predicted base on miRDIP database (with only top 1% of the most probable targets considered),
Data set 3. Pre-miRNA sequences in the SARS-CoV-2 RNA sequence that could potentially enter the human RNAi pathway, base on miRNAFold webserver.
Repository
Zenodo
Distribution License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Access Instructions and Link
This data is available under the CC-BY 4.0 License
Recommended Citation
Bartoszewski, Rafal; Dabrowski, Michal; Jakiela, Bogdan; Matalon, Sadis; Harrod, Kevin; Sanak, Marek; and Collawn, James, "Data sets v.1.1 for Perspective: SARS-CoV-2 may regulate cellular responses through depletion of specific host miRNAs" (2020). UAB Research Data Catalog. 52.
https://digitalcommons.library.uab.edu/datasets/52
