Supplement to: Sex and race differences in the risk of ischemic stroke associated with fasting blood glucose in REGARDS
Author ORCID
Tracy Madsen 0000-0001-5101-0776
Publication Date
5-17-2021
Abstract
Background: To investigate sex and race differences in the association between fasting blood glucose (FBG) and risk of ischemic stroke (IS).
Methods: This prospective longitudinal cohort study included adults age ≥45 years at baseline in the Reasons for Geographic And Racial Differences in Stroke Study, followed for a median of 11.4 years. The exposure was baseline FBG (mg/dL); suspected IS events were ascertained by phone every 6 months and were physician-adjudicated. Cox proportional hazards were used to assess the adjusted sex/race-specific associations between FBG (by category and as a restricted cubic spline) and incident IS.
Results: Of 20,338 participants, mean age was 64.5(SD 9.3) years, 38.7% were Black, 55.4% were women, 16.2% were using diabetes medications, and 954 IS events occurred. Compared to FBG FBG*race/sex=0.004). Analyses using FBG splines suggest that sex was the major contributor to differences by race/sex subgroups.
Conclusions: Sex differences in the strength and shape of the association between FBG and IS are likely driving the significant differences in the association between FBG and IS across race/sex subgroups. These findings should be explored further and may inform tailored stroke prevention guidelines.
Repository
Dryad
Distribution License
CC0 1.0 Universal - No copyright; this work is in the public domain
Access Instructions and Link
This data is public domain under the CC-0.0 License
Recommended Citation
Madsen, Tracy; Long, D. Leann; Carson, April P.; Howard, George; Kleindorfer, Dawn; Furie, Karen; Manson, JoAnn; Liu, Simin; and Howard, Virginia J., "Supplement to: Sex and race differences in the risk of ischemic stroke associated with fasting blood glucose in REGARDS" (2021). UAB Research Data Catalog. 63.
https://digitalcommons.library.uab.edu/datasets/63
