Heersink School of Medicine ETDs
 
Electronic versions of theses and dissertations from graduates of the School of Medicine, University of Alabama at Birmingham.

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Theses/Dissertations from 2023

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Epigenetic Aberrations in Systemic Sclerosis and Systemic Lupus Erythematosus, Peter C. Allen

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Macrophage IPLA2ß-Derived Lipid Signaling Contributes to Type 1 Diabetes Development, Abdulaziz Saad Almutairi

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Characterizing a Unique OPRM1 Expressing Neuronal Population in the Rat Nucleus Accumbens, Emma Andraka

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Sialylation of Epidermal Growth Factor Receptor by the Sialyltransferase ST6GAL1 Modulates Receptor Activity and Downstream Signaling, Katherine Ankenbauer

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Pharmacologic Proteasome Activators Ameliorate Alzheimer's-Like Pathology in Ad Fly Models, Mehar Bano

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Impact of Streptococcus Parasanguinis-Generated Reactive Nitrogen Species on Pseudomonas Aeruginosa Virulence and the Host Response, Joshua J. Baty

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Uncovering the Role of SPT5 in RNA Polymerase I Transcription Through Targeted Protein Degradation Via the Auxin Inducible Degron System in Saccharomyces Cerevisiae, Nathan Bellis

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Reduction of Sphingomyelinases Associated with Progranulin Deficiency and Frontotemporal Dementia, Nicholas R. Boyle

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Investigation into the Structure and Function of Tyrosyl-DNA Phosphodiesterase I's N-Terminal Domain, Evan J. Brettrager

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Modular Regulation and Function of the Polypyrimidine Tract Binding Protein 1 (PTBP1), Christine Carico

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Impact of Arthroplasty Surgery on the Local Immune Composition of the Knee Joint and Implications for the Periprosthetic Joint Infection, Kyle H. Cichos

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Neutrophil Heterogeneity and Alternative Granulopoiesis in Chronic Inflammatory Conditions, Ashley N. Connelly

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Strategies for HER2 Targeted PET Imaging, Maxwell Adams Ducharme

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Spatial/Temporal Zonation, Diversification, and Evolutionary Conservation of Kidney Resident Macrophage Subpopulations in Mice and Humans After Kidney Injury, Elise Nicole Erman

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Application of Machine Learning and Network Approaches to Prioritize Safe and Efficacious Drug Repurposing Candidates, Jennifer L. Fisher

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Differential Mechanisms of Intestinal Inflammation Drive Pathogenesis of Diabetic Retinopathy in Type 1 and Type 2 Diabetes, Jason Levi Floyd

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Molecular Influences of Racial Disparities in Pancreatic Neuroendocrine Tumors, Brendon Herring

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Molecular Determinants of Retroviral Gag Targeting to the Plasma Membrane for Assembly, Dominik Herrmann

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Unveiling the Molecular Features of Cancer Health Differences Through Multi-Omics Data Analysis, Fengyuan Huang

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Investigating Regulatory Mechanisms of Transcription by RNA Polymerase I, Abigail Kate Huffines

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The Long Non-Coding RNA NEAT1 Mediates Astrocyte Gene Expression and Hippocampus-Dependent Memory in Aging and Alzheimer's Disease, Ashleigh Burns Irwin

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Biochemical Characterization of RNA Polymerases I, II, and III and Its Therapeutic Implications, Ruth Qian Jacobs

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Understanding Molecular Mechanisms of Glioblastoama Resistance to Design Novel Combinatorial Therapies, Amber B. Jones

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Optimization of Progranulin Gene Therapy, a Potential Treatment for Frontotemporal Dementia, Shreya Natesh Kashyap

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The Molecular and Structural Basis of B Cell Epitope Targeting in Transplant Rejection, John T. Killian Jr

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Plasticity Characteristics of CXCR5+ CD4+ T Memory Cells and CXCR5- Non-TFH Memory Cells, Ching-En Lee

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Structural Characterization of Autoreactive IgG Fabs in the Context of IgA Nephropathy, Jordan Lingo

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Molecular Mechanisms of Amphetamine Abuse, Samuel James Mabry

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Investigating the Effects of Immune Checkpoint Inhibition and Combined Treatment with Evofosfamide on the Tumor Microenvironment Through Hypoxia Imaging, Kaytlyn Carter McNeal

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Early Life Stress and Endothelin Receptor Type A: Separate Roles in Mediating Colitis, Rachel Q. Muir

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Imaging Nanoscale Plasma Membrane Dynamics Reveals Diversity in Clathrin-Coated Vesicle Formation, Tomasz Jacek Nawara

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Manipulation and Dependence on Host Cell Cycle by Human RNA and DNA Viruses: Human Coronavirus OC43 and BK Polyomavirus, Jason M. Needham

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Chronic HIV Infection Influences the Immune Response to SARS-COV-2, Skye Opsteen

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A Tale of Two Waves: The Role of Genomic Enhancers in Regulating Transcriptional and Epigenetic Responses to Neuronal Activitiy, Robert A. Phillips III

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Understanding the Dual Role of the Oncolytic Viruses and Natural Killer Cells in Targeting Neuroblastoma, Colin Harrington Quinn

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T-BET Regulates the Maintenance and ASC Differentiation Potential of the Lymph Node and Lung Memory B Cell Compartments, Christopher A. Risley

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CIS-Regulatory Elements: Relevance for Alzheimer's Disease, Brianne Brazell Rogers

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Transcriptional Regulation in Early Stage CD4+ T Cell Activation and Differentiation, Andrew Ray Schroeder

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The Effects of Cannabidiol on Brain Temperature in Treatment-Resistant Epilepsy, Ayushe A. Sharma

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Expression of ST6GAL1 Imparts Stem-Like Cell Behaviors, Thereby Promoting Neoplasia, Sejal Sanjay Shinde

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Interactions Between Pseudomonas Aeruginosa and the Oral Commensal Streptococcus Salivarius, Sara Noelle Stoner

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Sex-Stratified Genetic Analysis of Gout and Comorbidities, Nicholas Andrew Sumpter

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Aberrant Signal Transduction of Neuronal Injury: Trauma and Toxicology, Alan Umfress

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Investigating the p53 Tumor-Suppressive Network and the Dynamics/Mechanism of p53 Loss of Heterozygosity, Jun Wang

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Regulating Cancer Cell Metabolism During Hypoxia-Reoxygenation: Examing the Interplay of Gasotransmitters and Glutaminolysis, Dianna L. Xing

Theses/Dissertations from 2022

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Distinct Clinical Manifestations Associated with Autoantibodies and Cytokines in Systemic Lupus Erythematosus, Fatima K. Alduraibi

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Elucidating the Role of STAT4 in CD4 T Cell Mediated Pathogenicity, Ashlyn E. Anderson

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The Role of the Bone Marrow Microenvironment in FLT3-ITD Acute Myeloid Leukemia Stem Cell Resistance to FLT3 Inhibition, Nicholas R. Anderson

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Induction of Antibiotic Activity Against Methicillin-Resistant Staphylococcus Aureus in Small Molecules Through Zinc Activation, Rachel Michaela Andrews

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Molecular and Cellular Mechanisms of Resistance Training-Induced Skeletal Muscle Hypertrophic Response Heterogeneity in Older Adults, Margaret Bell